LUSTIG: That’s a really tough question. We don’t want to turn off our reward system entirely. If we do, we get into trouble. We actually did this. We did this experiment with a medicine back in the early 2000s. That medicine was called Rimonabant . What it was was it was the anti-marijuana medicine. It blocked the endo-cannabinoid receptors in the brain, and by doing so reduced reward for alcohol and for food. In fact, people who took Rimonabant lost a fair amount of weight. It looked very promising. Until we started looking at the Phase 3 data and started realizing that a lot of these people became severely depressed, and many of them committed suicide . We didn’t realize it, until we did those Phase 3 trial. It was never approved here in the United States. Bottom line is, if you take away a reward, you take away the reason for living. Be careful about gene editing our rewards system.